Immunoglobulin (immunoglobulin) refers to animal proteins with antibody activity. It is mainly found in blood plasma, but also in other body fluids, tissues and some secretory fluids. Serum immunoglobulin (Ig) includes: IgG, IgA, IgM, IgD, IgE. its normal range: IgG 7.6~16.6g/L; IgA 0.71~3.35g/L; IgM 0.48~2.12g/L; IgD 0.01~0.04g/L; IgE 0.001~0.009g/L. So, what can cause the patient’s serum immunoglobulin can be elevated? The following is a brief introduction: various chronic liver diseases can cause elevated serum immunoglobulins such as: 1, autoimmune chronic hepatitis: autoimmune hepatitis is a chronic progressive liver inflammatory disease mediated by autoimmune reactions, which is clinically characterized by varying degrees of elevated serum aminotransferases, hypergammaglobulinemia, autoantibody positivity, and histological features of lymphocyte and plasma cell infiltrates as the main The disease is characterized clinically by varying degrees of elevated serum transaminases, hypergamma-globulinemia, positive autoantibodies, and histological features such as lymphocytic and plasma cell infiltrates, which can rapidly progress to cirrhosis and liver failure. The disease occurs worldwide, with a relatively high incidence in Europe and the United States, and its exact incidence and prevalence in China is unknown, but the number of cases reported in the domestic literature is increasing significantly. 2, chronic active hepatitis: patients will appear more obvious symptoms of hepatitis, such as abdominal distension, liver enlargement, splenomegaly, recurrent jaundice, darker face, spider nevus or liver palm on the forehead, repeated or persistent elevation of ghrelin, mostly accompanied by abnormal protein metabolism, reduced plasma albumin, reduced or inverted albumin/globulin ratio, etc.. The disease may be progressively aggravated, and some cases may develop into cirrhosis and liver cancer. 3.Cirrhosis: Cirrhosis is a common chronic progressive liver disease, which is formed by one or more causes of long-term or repeated effects of diffuse liver damage. Most of them are post-hepatitis cirrhosis in China, and a few are alcoholic cirrhosis and schistosomal cirrhosis. Pathological histology includes extensive hepatocyte necrosis, nodular regeneration of residual hepatocytes, connective tissue hyperplasia and fibrous septum formation, leading to structural destruction of liver lobules and pseudobullet formation, and progressive deformation and hardening of the liver to cirrhosis.