If you take two ibuprofen extended-release capsules at a time, it may aggravate the adverse reactions produced by ibuprofen, such as aggravating gastrointestinal adverse reactions, stomach pain, nausea, vomiting, abdominal pain, diarrhea, and even serious symptoms such as gastric ulcer, duodenal ulcer, and gastrointestinal bleeding. On the other hand, if two Ibuprofen extended-release capsules are taken at a time it may aggravate the damage of the drug to the liver or kidneys, and it can also cause water and sodium retention and high blood pressure. Therefore, when using ibuprofen extended-release capsules, you must strictly follow the doctor’s instructions or strictly follow the dosage in the drug’s instruction manual, and remember not to blindly increase the dosage of the drug, otherwise serious adverse reactions may occur.