Nutritional drugs for severe insomnia generally include vitamin B1, vitamin B12, glutamine and methylcobalamin tablets. 1. Vitamin B1: It can nourish the nerves and help prevent and treat the symptoms of vitamin B1 deficiency, such as athlete’s foot, neuritis, and indigestion, etc. Common adverse reactions are headache, irritability, fatigue, and diarrhea caused by overdose. 2. Vitamin B12: generally used for megaloblastic anemia, nutritional nerve, the more common adverse reactions are hypokalemia and hyperuricemia, etc., the contraindications are not yet clear. 3. Glutamine: used for neurosis, menopausal syndrome, nutritional nerves, etc., has the effect of sedation and sleep, the more common adverse reactions include nausea, vomiting, dry mouth and fatigue, etc., the contraindications are not clear. 4. Methylcobalamin tablets: can be used for peripheral neuropathy, nutritional nerves, common adverse reactions include nausea, vomiting, diarrhea, and loss of appetite, etc., for methylcobalamin tablets allergy is prohibited. In addition, the taking of the above drugs, there are certain risks, patients need to get the guidance of a specialist.