Red blood cell antibody screening can prevent the occurrence of transfusion reactions, including screening of donor serum, screening of pregnant women, and screening of recipients. 1. Screening of donor serum for antibodies prevents the transfusion of blood containing irregular antibodies to patients in need of transfusion to avoid hemolytic reactions. 2. Screening for irregular antibodies in pregnant women can detect irregular antibodies as early as possible so that prevention and treatment of hemolytic disease of the newborn can be started during pregnancy, thus reducing the harm of irregular antibodies to the fetus and the newborn. 3. If the recipient has a history of blood transfusion or pregnancy, or if a large amount of blood transfusion is required within a short period of time, irregular antibody screening should be performed so that such antibodies can be detected in a timely manner in order to avoid the occurrence of transfusion reactions. If irregular antibodies are present, it is recommended to consult a doctor in time to clarify the cause of the disease with the help of the doctor and carry out targeted treatment or therapy.