Cholangiography agents affect different people in different ways. Patients with allergies, sensitivities, and kidney disease may experience skin rashes, edema, nerve damage, kidney damage, and other hazards. Cholangiography is done by injecting a cholangiography agent into the body so that it enters the bile ducts and then images of the lesion are presented on a machine. The commonly used contrast agents in the clinic are cholangiography sodium iodine, alfenamic acid, sodium iodopeptide, etc. These ingredients are relatively safe and will not cause harm to the body under normal circumstances. For people with allergies, it is likely that they will also be allergic to cholangiography agents and develop urticaria, angioedema, skin rashes, and so on. If the patient is allergic to iodine, the use of cholangiography is prohibited, otherwise it may lead to anaphylactic shock, which may endanger the patient’s life. For sensitive people, cholangiography agent may cause neurological provocation, headache, nausea and other symptoms. For patients with kidney disease, cholangiography agent needs to be excreted through the kidneys, so it may lead to the occurrence of kidney damage. In addition, other symptoms may occur with the use of cholangiography agents. It is recommended to go to the hospital in time for checkups to clarify the cause of the discomfort, and then handle the situation accordingly.