Systemic lupus erythematosus (SLE) is mainly controlled by general treatment and medication. Systemic lupus erythematosus is a systemic connective tissue disease that can involve multiple systems and organs. Early symptoms are atypical, but multiple organ involvement can occur in the later stage, with common symptoms such as skin rashes, mucosal ulcers, alopecia, joint pain, and muscular weakness, etc. The treatments are based on general treatment and drug therapy. 1. General treatment. Adjust the mood and mind. Avoid the use of estrogen-containing drugs, avoid strong sunlight and ultraviolet radiation, and try not to contact with chemicals. 2. Drug treatment. Commonly used drugs for SLE include non-steroidal anti-inflammatory drugs (ibuprofen, etc.), anti-malarial drugs (hydroxychloroquine, etc.), glucocorticosteroids (prednisone acetate, etc.), immunosuppressants (azathioprine, methotrexate, cyclophosphamide, merti-methacrylate), and so on. All of the above drugs should be selected under the guidance of the doctor according to the patient’s own situation. It is recommended that SLE patients should consult the rheumatology and immunology department of regular hospitals in a timely manner, standardize the diagnosis and treatment under the guidance of doctors, and undergo regular checkups.