Lymph node pain without inflammation may be caused by leukemia, systemic lupus erythematosus, lymphoma and other diseases, the patient should consult a doctor in time, to clarify the cause of the disease and then treatment. 1. Leukemia: malignant clonal disease of hematopoietic stem cells, patients will have lymph node enlargement, lymph node pain, high fever, anemia, and other symptoms, can use methotrexate, imatinib and other drugs for treatment. 2. Systemic lupus erythematosus (SLE): an autoimmune disease of unknown etiology that can invade multiple systems throughout the body, patients will have erythema of the cheeks, lymph node pain, muscle pain, fatigue and other symptoms, such people should pay attention to maintaining a regular life, and the use of aspirin, chloroquine, methotrexate and other medications for treatment. 3. Lymphoma: Lymph node pain may also be caused by lymphoma, the patient will also have fatigue, lethargy, enlarged lymph nodes, fever and other symptoms, which can be treated with chemotherapy drugs, and hematopoietic stem cell transplantation if necessary. Lymph node enlargement caused by these diseases is often painless, but there may be pressure on the surrounding tissues and painful symptoms. The diagnosis should be followed by appropriate treatment as prescribed by the doctor.