Endothelial biopsy may cause delayed menstrual cycles, and in severe cases, may lead to decreased menstrual flow or amenorrhea. Endothelial biopsy is an invasive operation that is performed under hysteroscopic surveillance at the site of the suspected lesion for pathologic examination, which may cause infection after the operation and increase the probability of cervical adhesion and uterine adhesion, and the operation may also have a certain impact on the patient’s psychological well-being, which may delay the menstrual cycle, and in severe cases, lead to menstrual flow reduction or amenorrhea. Therefore, it is recommended that women pay more attention to their own physical condition after endothelial biopsy, and judge whether there is any abnormality according to their own actual situation. If the patient’s menstruation is delayed after endothelial biopsy or the symptoms continue to be unimproved, she should go to the hospital in time to find out the reason, and actively comply with the medical standardized treatment if necessary.