Erythromycin Isotretinoin Gel can work to treat blackheads. Blackheads, also known as open pimples, are caused by abnormal localized development of hair follicles, manifesting as dark spots in visibly enlarged pores, and are classified as mild acne. Isotretinoin Erythromycin Gel is a compounded formulation, and its ingredients mainly contain isotretinoin and erythromycin. Erythromycin Isotretinoin Gel is mainly used for the topical treatment of mild to moderate common acne, and is also effective for inflammatory and non-inflammatory skin lesions. Patients should be aware that this product may cause stinging, burning, and irritation, and that erythema and peeling may occur at the site of application. In addition, the drug is contraindicated for pregnant and lactating women and those who are allergic to any of the components of the product. It should be noted that patients who develop blackheads should use the drug under the advice of a doctor, and patients should not use the drug on their own to avoid delays.