Pain in large teeth may be due to caries, pulpitis, periapical inflammation, wisdom tooth pericoronitis and other reasons. 1. Caries: After the tooth is decayed, when the depth of decay is close to the pulp, there will be sensitivity or pain such as food impaction pain, hot and cold stimulation. 2. Pulpitis: After caries reaches the pulp, acute or chronic inflammation of the pulp will occur, and the tooth will have spontaneous pain, night pain, hot and cold stimulation pain. 3. Periapical inflammation: When the inflammation of the pulp develops further, there will be periapical inflammation, which is manifested as occlusal pain, knocking pain, swelling and pain, and even the formation of gingival fistula. 4. Wisdom tooth pericoronitis: due to the poor position of wisdom teeth, the formation of blind pockets, the body’s resistance to decline, poor oral hygiene, resulting in wisdom tooth pericoronitis, there will be swelling and pain, occlusal pain and so on. There are many reasons for the pain of the big teeth, if you find pain, it is recommended to go to the regular dental hospital in time to find out the reasons and treat the symptoms.