Gout remission knee and ankle discomfort, may be chronic gout arthritis or gout stone caused by uric acid treatment should be carried out, if necessary, surgical treatment to remove the gout stone, at the same time need to carry out dietary modification. 1. Uric acid-lowering treatment: the long-term treatment of hyperuricemia in gout patients can be carried out by taking febuxostat tablets as prescribed by the doctor. Adverse reactions mainly include abnormal liver function, diarrhea, etc. It should not be used with azathioprine and thiopurine. Benzbromarone capsule can be applied to simple hyperuricemia and gouty arthritis non-exacerbation period of treatment. Adverse reactions mainly include gastrointestinal symptoms such as nausea and vomiting, skin rash, renal colic, and severe hepatotoxicity. It is contraindicated in patients with moderate to severe renal impairment and in patients with kidney stones. Drink plenty of water during medication. 2. If necessary, we can choose to eliminate the gout stone and perform corrective surgery on the destroyed joints. 3. In daily life, we need to pay attention to quit alcohol, reduce the intake of high-purine food such as seafood, animal offal, prevent strenuous exercise or cold, drink a lot of water, quit smoking and so on. If gout remission knee and ankle discomfort should be timely to the hospital rheumatology and immunology department, under the guidance of the doctor standardized treatment, regular follow-up.