The normal value of leukocytes is (4~10)×10^9/L, leukocytes 46.96×10^9/L is significantly higher than the normal value, it is considered that it may be infectious diseases (need antibiotic anti-infection treatment), hematological diseases (need chemotherapy, etc.), rheumatic diseases (can be given to glucocorticosteroids, methotrexate and other drugs to inhibit immune-inflammatory reaction), need to be analyzed specifically. 1. Infectious diseases: Infectious diseases such as bacterial infections will have elevated white blood cell counts, according to the causative organisms need to choose sensitive antibiotic anti-infective treatment, commonly used antibiotics include penicillin (e.g., amoxicillin clavulanic acid potassium, etc.), cephalosporins (e.g., cefdinir, etc.) and so on. 2. Hematological diseases: leukemia will have elevated white blood cell counts and can be treated with combination chemotherapy and stem cell transplantation. Different chemotherapy regimens can be given according to different types of leukemia, such as VP regimen (vincristine, prednisone) for acute lymphoblastic leukemia, IA regimen (nortriptyline, cytarabine) for acute myeloid leukemia. 3. Rheumatic diseases: Rheumatic diseases such as rheumatoid arthritis, during the acute exacerbation of which the leukocyte count will be elevated, which is related to autoimmune inflammatory reaction, glucocorticoids, methotrexate and other drugs can be given to inhibit immune inflammatory reaction. If the white blood cell count reaches 46.96×10^9/L, it is necessary to consult a doctor immediately and start treatment as soon as possible after the diagnosis is clear to avoid delaying the condition.