Isosorbide nitrate and aspirin can generally be taken together, but both drugs have certain contraindications, it is recommended that under the guidance of a doctor reasonable use of drugs. 1. Isosorbide nitrate: isosorbide nitrate can be used for long-term treatment of coronary heart disease, treatment of persistent angina after myocardial infarction, and prevention of angina. However, it should be used with caution in acute myocardial infarction with low filling pressure, aortic or mitral stenosis, postural hypotension, and increased intracranial pressure. 2. Aspirin: Aspirin’s inhibitory effect on platelet aggregation is mainly used for the prevention of myocardial infarction and the reduction of transient ischemic attack. But for aspirin and other salicylic acid drugs allergy, as well as the existence of gastroduodenal ulcer, or bleeding tendency of the crowd should be avoided. It is recommended that patients strictly follow the doctor’s instructions to use the drug, avoid self-medication, discomfort in the process of taking the drug, should stop immediately.