Large joint pain may be caused by traumatic diseases, arthritis, systemic lupus erythematosus and other factors. 1. Traumatic diseases: When the large joints and ligaments around the joints are subjected to direct violence, indirect violence and other traumatic injuries, they will be easily damaged, resulting in symptoms of large joint pain. 2. Arthritis: If autoimmune disease occurs, it will be easy to produce more antibodies, and the increased antibodies will attack its own joints, resulting in joint pain; degenerative osteoarthritis will also occur in the large joints of the pain, such as hip joints, knee joints, ankle joints and so on. 3. Systemic lupus erythematosus (SLE): When the body produces inflammatory factors, it will easily lead to joint damage, and when the disease has an acute attack, large joint pain will occur. There are many reasons for large joint pain, if it is difficult to relieve, you should go to the hospital in time, after clarifying the cause of the disease, under the guidance of the doctor for proper treatment.