Thyroglobulin antibody is a common autoantibody found in the serum of patients with autoimmune thyroid disease. Generally, the normal value is 11.4-20 mg/L. It can be elevated to varying degrees in malignant tumors of the thyroid gland, such as follicular, papillary or interstitial thyroid carcinoma. In addition, non-tumor thyroid diseases can also cause elevated thyroglobulin antibodies, such as hyperthyroidism, thyroid tumors, subthyroiditis, and Hashimoto’s thyroiditis, all of which can result in elevated thyroglobulin antibodies in the blood. Therefore, we need to further clarify the type of pathology of the patient by taking into account the clinical presentation as well as the degree of alteration of laboratory findings, ultrasound and MRI results.