Total sleeplessness for more reasons, the common reasons are the following: First, environmental factors, some people can not sleep after a business trip or moving, due to changes in the sleep environment, the sleep environment temperature, humidity and sound, light stimulation can also cause sleeplessness. Second, physiological factors, some people in a small amount of alcohol or tea, coffee, temporary brain excitement can lead to sleeplessness. Third, psychological factors, such as in the encounter of more important things, before participating in important activities or psychological always have some entangled things, etc., will be too much thought caused by sleeplessness. Fourth, mental illness, such as anxiety or schizophrenia patients, excitement is relatively high, long-term in a state of hyperactivity, very little sleep, long periods of time without sleep. Fifth, somatic diseases, liver disease patients in the prodromal phase of hepatic encephalopathy and some brain patients, hyperthyroidism patients, there will be increased speech, easily agitated, insomnia. Sixth, the role of certain drugs in the treatment of the disease process, such as excitatory central drugs, such as sodium cytarabine, piracetam, aminophylline, dexamethasone.