The presence of urinary protein in diabetic patients suggests a combination of diabetic nephropathy, and diabetic nephropathy can be categorized into early and clinical stage nephropathy. Early diabetic nephropathy is the urine analysis of urine protein trace, less than a plus sign, but the urine microalbumin is significantly elevated. Clinical stage diabetic nephropathy is when the patient has more than one plus sign of urine protein in the urinalysis, again with a more pronounced elevation in the urine microalbumin level. For early or clinical stage diabetic nephropathy patients should be given active drug treatment, in addition to blood glucose control, but also pay attention to strengthen the control of blood pressure, in addition to oral microcirculation to improve drugs such as pancreatic kininogenase, to reduce urinary protein drugs such as Bailing capsule, Huangkui capsule and so on, will have a better therapeutic effect. In addition, it is necessary to improve the relevant examination to exclude other causes of renal damage.