Emphysema is not a genetic disease. It is a pathological change, which refers to a pathological state in which the elasticity of the lung tissue is reduced for various reasons, resulting in hyperinflation and an increase in air content. Emphysema is often secondary, meaning that it can be caused by a variety of factors, such as chronic infection of the lungs or chronic bronchitis, which can lead to the development of emphysema. There is a relationship between emphysema and genetic factors, for example, patients with alpha1-antitrypsin deficiency are prone to emphysema. However, this does not mean that emphysema is a genetic disease, but only that it has a certain genetic susceptibility.