Leukodystrophy, professionally known as Behçet’s disease, has no specific serologic markers and no abnormalities on antinuclear antibody profiling. Behçet’s disease is a chronic disease characterized by recurrent oral and vulvar ulcers, ophthalmia, and skin lesions involving multiple systems. The diagnosis of Behçet’s disease does not depend on serologic tests, and there are no abnormalities in the antinuclear antibody profile, ANCA, or antiphospholipid antibodies. The needle prick test is currently the only diagnostic test for Behçet’s disease that has a high degree of specificity. Behçet’s disease can be highly suspected if a patient presents with recurrent vulvar oral ulcers, skin lesions (characteristic erythema nodosum), and a positive pinprick test. Behçet’s disease is difficult to diagnose and requires the guidance of an experienced rheumatologist for examination and treatment. It can be treated with drugs such as celecoxib, colchicine and thalidomide as prescribed by the doctor. It is recommended that patients with Behçet’s disease should consult a rheumatologist in a timely manner, under the guidance of the doctor for standardized treatment and regular follow-up.