Minor fractures caused by myeloma can be relieved by external fixation, braking, and anti-tumor therapy. In case of severe fractures, surgery is required. One of the common complications of myeloma is fracture, which is caused by cancer cells invading the bone. Such fractures are mostly caused by the primary tumor, so anti-tumor treatment is mainly needed. For minor fractures, simple immobilization and braking can be carried out, and the fracture can gradually heal naturally after the primary tumor is relieved by anti-tumor treatment. If myeloma leads to serious fracture, such as rib fracture piercing the lung leading to pneumothorax, urgent surgical treatment is needed to repair the ruptured lung. If the fracture occurs in the lumbar spine and damages the spinal cord, urgent surgery is also needed to fix the fracture with internal fixation and reinforce the lumbar spine to prevent nerve damage that can lead to paralysis. If the fracture is caused by myeloma, it is recommended to go to the hospital in time, and under the guidance of specialists to give targeted treatment or therapy according to the fracture situation.