Clinically, “pancreatic ca” is often used to refer to “pancreatic cancer”, i.e. pancreatic cancer. Pancreatic cancer is the most malignant gastrointestinal tumor, its early onset is insidious, and most of the patients have lost the best time for surgical resection when diagnosed. According to the guideline for diagnosis and treatment of pancreatic cancer, the risk factors, diagnosis and treatment are as follows. 1. Risk factors: including smoking, obesity, alcoholism, chronic pancreatitis, etc. The risk of pancreatic cancer increases significantly in those who are exposed to naphthylamine and benzene compounds. Diabetes is an independent risk factor for pancreatic cancer. 2. Diagnosis: Clinical symptoms include epigastric discomfort, weight loss, nausea, jaundice, steatorrhea and pain, which are not specific. For patients with clinical suspicion of pancreatic cancer and those at high risk of pancreatic cancer, non-invasive means of screening should be preferred, such as serological tumor markers (e.g., CA199), ultrasound, pancreatic CT or MRI. 3. Treatment: If surgical resection is feasible after evaluation, elective surgical resection should be performed, and chemotherapy should be supplemented as early as possible after surgery. For those unresectable after evaluation, active chemotherapy should be given. Patients with suspected pancreatic cancer should go to local regular hospitals as early as possible for consultation and active treatment to avoid delay.