The end of the ileum can be seen 5 mm ulcer, must be biopsied means only enteroscopic forceps ulcer local mucosal tissue for biopsy, through histopathological examination can clarify the pathological nature of the ulcer. Enteroscopy found small ulcers at the end of the ileum, this situation should be considered chronic ileitis caused by ulcers, Crohn’s disease, malignant ulcers and other possibilities, only further biopsy histopathological examination can be determined. If the pathological examination found that there is hyperplastic granulation tissue around the ulcer, we should consider the possibility of Crohn’s disease; if it is only ordinary inflammatory hyperplasia, we should consider chronic enteritis; if the pathological examination found atypical hyperplasia or heterogeneous cells, we should consider that the ulcer has a tendency to malignant transformation or belongs to malignant ulcers. Combined with clinical symptoms, further biopsy of the local mucosa of the ulcer should be performed as prescribed by the doctor to clarify the pathological nature of the ulcer and guide the clinical intervention program.