High fever can cause some effects on kidney function. High fever is caused by the body being attacked by bacteria, viruses and pathogenic microorganisms, such as mycoplasma and chlamydia, or fungi, and the body produces some endogenous pyrogenic substances, such as interleukins, tumor necrosis factor, bradykinin, leukotrienes, prostacyclin and so on. The accumulation of these substances in the body will cause hyperthermia and at the same time cause different degrees of stimulation and load on the kidneys and liver, so high fever will appear to affect the kidney function. In addition, when patients have high fever for a long time, they will also become dehydrated, and when they become dehydrated, they will have significant ionic disorders, which will also cause different degrees of burden and load on the kidney function, and therefore will also have an impact on the kidney function. Therefore, when choosing antibacterial, anti-inflammatory and antipyretic drugs for the treatment of high fever, try to choose drugs that have the least impact and damage on kidney function.