The difference between Pepto Bismol and Dermaplan is as follows: 1. Their ingredients are different. The main ingredient of Pepto Bismol is mupirocin, which is an antibiotic. The difference between Pepto-Bismol and Dermapen is that they have different indications. Pepto-Bismol is a topical antibiotic that is mainly used for skin infections caused by sensitive bacteria, such as impetigo, boils, eczema and other primary skin infections. It is mainly used for primary skin infections caused by sensitive bacteria, such as pustules, boils, folliculitis and other primary skin infections as well as eczema co-infections and secondary skin infections such as superficial trauma co-infections that do not exceed 10cm x 10cm in area. Dermaplanin is mainly used for neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema. Dermapen contains hormones, so long-term use may lead to skin atrophy, capillary dilation, pigmentation and secondary infections, and occasionally allergic reactions, and should not be used for a long time. The more common side effects of Pepto-Bismol are localized burning sensation of the skin and itching, erythema, stinging sensation or dryness, which usually do not require discontinuation of the drug.