Hemiparesis in patients with chronic granulocytic leukemia depends on whether the hemiparesis is related to the chronic granulomas. If the hemiparesis is caused by cerebrovascular disease, it is necessary to treat the chronic granulomas while treating the cerebrovascular disease. If the hemiparesis is caused by leukemia invading the central nervous system, treatment includes drug therapy and allogeneic stem cell transplantation.
Treatment of hemiplegia due to cerebrovascular disease includes blood pressure lowering, lipid lowering, antiplatelet therapy such as nifedipine, atorvastatin, aspirin, etc. Thrombolysis may be needed in the acute stage.
Treatment for lentigo and lentigo with central involvement includes:
1. tyrosine kinase inhibitors: the drugs of choice for chronic granulocytic leukemia, such as imatinib, nilotinib and dasatinib.
2. Interferon: mainly used for tyrosine kinase inhibitor-resistant, intolerant people and various reasons temporarily unable to use tyrosine kinase inhibitors or unable to adhere to long-term users.
3. Hydroxyurea: generally recommended for chronic granulocytic leukemia patients with high white blood cell counts.
4. Allogeneic stem cell transplantation: currently the only way to cure, but transplantation has the problem of difficulty in finding suitable donors and high risk of transplant-related diseases and death.
5. Lumbar puncture with intrathecal drug injection and whole brain whole spinal cord radiotherapy: an effective treatment for CNS leukemia, drugs include cytarabine and methotrexate.
If hemiplegia occurs in patients with chronic granulocytic leukemia, it is recommended to go to the hospital in time, under the guidance of the doctor for standardized treatment, and the above drugs should not be taken by oneself.