Generically known as sacubitril valsartan, Nosintrex is not usually a medication that can be discontinued after one year of stenting. If the medication needs to be stopped due to a medical condition, it is recommended that the decision be made after a comprehensive evaluation by a physician. Sacubitril valsartan belongs to the compound preparation, which is mainly used for the treatment of chronic heart failure with reduced ejection fraction, as well as to reduce the risk of cardiovascular death and heart failure; the drug needs to be taken regularly for a long period of time after stenting, so it is usually not possible to stop taking the drug one year after stenting in order to avoid the recurrence of the disease. If the drug needs to be stopped due to the condition of the patient, or if there are abnormalities in serum creatinine, serum potassium, angioedema and other adverse reactions after taking the drug, the doctor can decide whether to stop using the drug or to change to other medications after a comprehensive assessment of the condition of the patient, and remember not to stop taking the drug on your own, to avoid any adverse reactions. Secondly, the use of the drug may also cause hemoglobin, erythrocyte pressure and other indicators of abnormality, for severe hepatic impairment, biliary cirrhosis, cholestasis is prohibited; allergic to the relevant components of the product is prohibited. It has embryotoxicity, it is not recommended for pregnant women; in the process of using the drug also need to pay attention to monitoring liver and kidney function, electrolytes and so on. All of the above medications should be used under the guidance of a doctor, avoid self-medication, so as to avoid adverse consequences.