High 25-hydroxyvitamin D levels are mainly due to accumulation in the body caused by excessive oral vitamin D. The first step is to stop taking vitamin D. All forms of vitamin D should be discontinued, and if necessary, hormone therapy can be performed to inhibit absorption. 25-hydroxyvitamin D elevation will produce clinical symptoms, including nausea, vomiting, limb weakness, and psychiatric symptoms, and in severe cases, frequent urination and dry mouth. In addition to the above statements, treatment is followed by adequate nutritional supplementation, maintaining water-electrolyte balance, and close attention to changes in vital signs. When the basic symptoms disappear after a period of discontinuation, the application can be continued because 25-hydroxyvitamin D is a fat-soluble vitamin, and if too much is taken orally, it will cause accumulation in the liver and further produce toxic symptoms.