Hypertensive disease to take the drug blood pressure is still high, that is, the control does not reach the standard, this situation to check the causes: 1, to exclude whether there is secondary hypertension, a, renal substantial hypertension, including a variety of primary glomerulonephritis, tubular interstitial disease, diabetes, nephropathy, monoclonal immunoglobulin-related kidney disease, etc.. Second, renal artery stenosis and other vascular-induced hypertension. III. Obstructive sleep apnea syndrome. IV. Primary aldosteronism, and other endocrine hypertension. V. Pheochromocytoma or paraganglioma. Sixth, drug hypertension, is a conventional dose of the drug itself, or the drug and other drugs interact with each other, and caused by hypertension. 2, eat the right medicine, level 2 hypertension above the choice of two antihypertensive drugs, level 3 hypertension even need to use three antihypertensive drugs combined treatment. This is the wrong treatment method. Go to a regular hospital cardiology department, monitor 24-hour ambulatory blood pressure, and check other auxiliary tests, including kidney function and urinalysis, to choose the appropriate antihypertensive drug. It is important to emphasize individualized treatment to lower blood pressure, and non-pharmacological treatment, such as exercise, low salt and low fat diet, should be carried out along with drug treatment.