Gliclazide and metformin can generally be taken for a long time in the absence of adverse reactions and contraindications. Gliclazide is a drug that promotes insulin secretion, and metformin is a glucose-lowering drug, both of which are mainly used in the treatment of diabetes mellitus, with a more prominent clinical effect, and both of which can be used as a long-term glucose-lowering drug in combination. Gliclazide and metformin in the lowering of sugar at the same time, may also appear hypoglycemia, regurgitation and lactic acidosis and other adverse reactions, so the use of drugs need to do a good job during the liver function, blood glucose, and renal function tests. In addition, liver disease, kidney disease and diabetic ketosis patients are prohibited, avoid drinking alcohol after taking the drug. Gliclazide and Metformin should be taken under the supervision of a doctor, and liver and kidney function should be regularly reviewed and monitored. Prompt medical attention is recommended in case of discomfort.