Nine-valent generally refers to the nine-valent HPV vaccine, which comes in three doses. The main purpose of the HPV vaccine is to prevent cervical cancer caused by human papillomavirus infection, and it can prevent 9 types of viruses, including 6, 11, 16, 18, 31, 33, 45, 52 and 58. Currently, the nine-valent HPV vaccine is administered in three doses by intramuscular injection according to the 0, 2, and 6-month immunization program, and is applicable to women aged 16 to 26. At the same time, the injection of the nine-valent HPV vaccine can also prevent vaginal cancer, anal cancer, warts and so on. If the patient is allergic to the vaccine or in acute fever, pregnancy, or has been vaccinated with quadrivalent HPV vaccine, the injection of the nine-valent HPV vaccine is contraindicated to prevent accidents. After vaccination, pay attention to stay in hospital for observation for a period of time in order to deal with unexpected situations. It is recommended to receive the full course of HPV vaccine at regular hospitals on time, strengthen local skin care after injection, and avoid foreign body friction and stimulation in order to prevent infection.