Chronic urticaria patients can choose antihistamines, H2 receptor antagonists and other drugs under the guidance of the doctor and other methods of correct combination of drugs. 1. Second-generation antihistamines: patients can first choose loratadine, cetirizine and other second-generation antihistamines under the guidance of the doctor for treatment, which can effectively control the symptoms. 2. Combination of drugs: when the effect of second-generation antihistamines is not good, it can be combined with first-generation antihistamines, common drugs include chlorpheniramine maleate, cyproheptadine and so on. In addition, the third-line treatment of chronic urticaria has tretinoin tablets or cyclosporine. Chronic urticaria patients are recommended to consult a doctor in a timely manner, under the guidance of the correct combination of drugs, the treatment should pay attention to follow the doctor’s instructions, can not change the dosage of their own.