The common causes of lumpy swelling and pain in the anus include hemorrhoids, condyloma acuminatum, perianal abscess, etc. Treatment includes medication such as glucocorticosteroids, surgical treatment, and so on. 1. Hemorrhoids: Hemorrhoids are diseases caused by the venous plexus at the lower end of the anorectal tube that are swollen with blood, often divided into internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids. Patients often manifest perianal itching, prolapse, blood in the stool, pain and so on. Commonly used drugs include hemorrhoidal suppositories or creams, pain can be used ibuprofen, etc. Conservative treatment is ineffective can be treated by surgical excision. 2. Warts: Warts is a sexually transmitted disease caused by the human papilloma virus, the patient’s genitals and the skin near the anus can appear in varying sizes of reddish particles, which can be accompanied by ulceration and bleeding. The medication includes imiquimod cream, onychomycosis ointment, etc. If the condition is serious, it can be treated by surgical excision. 3. Perianal abscess: Perianal abscess refers to suppurative infection of the tissues around the anorectal canal and intestine, patients may have persistent pain around the anus and early hard lumps, aggravated by coughing and defecation. Commonly used drugs include cefdinir, metronidazole, erythromycin ointment, etc. Once diagnosed, patients should promptly undergo surgery to incise and drain the abscess. It is necessary to choose the appropriate drugs under the guidance of the doctor. When patients have perianal discomfort, they need to go to the hospital immediately for treatment.