In China, some PD patients, especially those with early-onset disease (starting at less than 50 years of age), have obvious phobias about levodopa, fearing that there will be no medicine available after the “honeymoon period” or that there will be anisotropy. Some patients or their family members blindly expanded/publicized the side effects of Methyldopa through the Internet or communicating with the patients around them, and some of them regarded Methyldopa as a “poison”, and even if they were about to become bedridden, they would firmly resist taking the drug, putting their quality of life completely aside. There are also some patients who take Methyldopa with very obvious effect and think that they have been sick for a long time and there is no need to look for a doctor in the future. They blindly increase the dosage of Methyldopa by themselves at home, which leads to serious complications and regrets. The above two phenomena have been encountered in my clinic, and both of them are undesirable. They have committed the two extremes of “left” or “right”, which are in fact not good, and the Chinese Confucianism “middle-of-the-road approach” has a significant role in the treatment of PD. Chinese Confucianism, “the middle way” in the treatment of Parkinson’s is a very good idea, we can not be radical about anything, anything (including drugs) have its two sides. From the doctor’s point of view, the most important goal of the patient is to relieve his pain to the greatest extent possible, which is a natural match with the doctor’s idea. In the case of Parkinson’s patients, methyldopa is one of the most commonly used medications, and studies have found that all Parkinson’s patients ultimately require levodopa treatment. Therefore, it is very important to look at the use of levodopa objectively. To summarize, there are the following three common misconceptions: Misconception 1: Levodopa treatment will lose its therapeutic effect after about 5 years; Misconception 2: It is toxic to dopaminergic neurons; Misconception 3: It will lead to the development of anisotropy. In fact, the total daily dose of levodopa is too large to induce the development of anisotropy, and the more important reason is due to the progression of their own disease. Moreover, levodopa-induced anisotropy can be reduced or delayed by a combination of other medications by an experienced movement disorders physician. The 2009 edition of the guidelines suggested that delaying levodopa use might have the effect of delaying disease progression. However, this is no longer stated in the 2014 edition of the guidelines. The latest evidence suggests that levodopa is not toxic to dopaminergic neurons, that starting treatment does not accelerate the disease process, and that long-term treatment with the right dose of levodopa can slow the disease process. So how should we take Methyldopa/Hypnin correctly to utilize its advantages and reduce possible side effects? We should pay attention to the following aspects: 1. Reasonable selection of the time to start taking the drug – as I said a while ago, if the symptoms affect the daily life or take other medications with poor efficacy should be timely started to take methyldopa or polypheniramine, do not overly delayed (can not be hard to carry on); 2. Control of the dosage of the drug –For early-stage patients, the total daily dose should be controlled below 300-400 mg (equivalent to a daily total of 2 tablets of methyldopa/approximate 2.5 tablets of polypheniramine) as far as possible, and some studies have confirmed that controlling the total daily dose in this range does not increase the risk of exercise complications; 3. Consideration of multi-drug combination therapy –For taking methyldopa or polypheniramine alone, as the controlled dose may lead to unsatisfactory efficacy, other anti-drugs can be considered, reflecting the concept of multi-target therapy; 4. Let the drug be fully absorbed – whether the drug can be fully absorbed has a great influence on whether methyldopa is effective. Therefore, the drug should be taken on an empty stomach (one hour before meals), avoid taking milk and eggs at the same time, because dietary proteins can affect the absorption of the drug; for slow-absorbing patients, consider taking gastric drugs such as morpholine before taking methyldopa; chewing or crushing methyldopa tablets and then taking them orally. The specific choice of which way to take the drug, need to let the doctor to decide through the face-to-face consultation, and also need to be followed up through a period of time, to understand the feeling after taking the medication of Palmers. In conclusion, levodopa is like a double-edged sword, we need to look at it objectively, if it is used properly, it will be beneficial to the patient, but if it is not used appropriately, it may have adverse effects on the patient. One of the best ways to avoid the shortcomings of this sword is to seek the assistance of a doctor who specializes in movement disorders.