HPV (human papillomavirus) 18 positive suggests that type 18 HPV infection, the patient does not necessarily lead to cancer, long-term infection may cause cancer, but more than a decade or even decades, patients should pay attention to timely intervention and treatment, regular review. HPV18 infection is self-limiting, and the vast majority of people can heal themselves after infection, or be cured through medical intervention. Very few people will be infected repeatedly for a long time, and most of them can become asymptomatic lifelong carriers, of which only a few will cause cancer. HPV18 infection leading to cancer needs to go through low-grade lesions, high-grade lesions and cervical cancer, which takes ten or even several decades, with large individual differences, and the time to cancer may be shortened for individuals with poor resistance. Timely treatment during the development of cervical cancer will not lead to a poor prognosis. Therefore, HPV18 positivity has a very small chance of causing cancer, so there is no need to be too anxious. However, since long-term infection can lead to cervical cancer, it is important to have regular cervical screening and timely intervention after infection.