Generally the prognosis for surgery for giant cell tumor of bone is relatively good, and pain usually does not develop after a few years, but giant cell tumor of bone may recur after surgery and pain may develop. There is no definitive information on the development of pain years after surgery for giant cell tumor of bone. Giant cell tumor of bone is a type of giant cell composed of proliferating monocytes and osteoblast-like multinucleated giant cells. It is an aggressive primary benign bone tumor with a tendency to recur locally, is highly aggressive, and has a large lysogenic and destructive effect on bone. Surgery for giant cell tumor of bone generally has three modes: lesion scraping and bone grafting, resection of tumor segment and bone grafting, and artificial joint replacement. Due to the strong tendency of giant cell tumor of bone to recur locally, recurrence may occur after surgery with painful symptoms consistent with giant cell tumor of bone. Osteoblastoma surgery can also be associated with complications such as non-healing of the grafted bone and periarticular fractures, the occurrence of which can also lead to pain. This is because there is no exact time for recurrence after surgery for osteoblastoma. Therefore, there is no information that suggests that pain will occur after several years after surgery for giant cell tumor of bone. If a patient develops pain after surgery, he or she should go to the hospital for examination and receive treatment after the cause is clarified.