Dual-antiplatelet therapy is mostly used to treat with aspirin and clopidogrel at the same time, and the side effects include gastrointestinal reactions, gastrointestinal bleeding, liver and kidney function impairment. Dual-anti-therapy means the use of double drugs, for anti-platelet aggregation, usually applied in the acute stage of cerebral infarction and myocardial infarction, because of the simultaneous use of two anti-platelet aggregation drugs, the risk of bleeding and adverse drug reactions will be increased accordingly. Currently used double drugs are mainly aspirin and clopidogrel. Both may cause gastrointestinal bleeding, cerebral hemorrhage, etc., and the risk of bleeding is significantly increased when they are used together. Both may cause damage to liver and kidney function, so they are contraindicated in people with severe liver and kidney insufficiency. Aspirin also causes more common gastrointestinal reactions, such as nausea, abdominal distension, abdominal pain and so on. The use of the drug should be under the guidance of a professional doctor, and it is recommended to consult a doctor in a timely manner to standardize the treatment.