The causes of oedema in the eyes need to be differentiated. If one eye is swollen, local causes may play a leading role, such as trauma, allergies, insect bites or diseases of the eye itself, which can be treated at the ophthalmology department. If the swelling is bilateral, it is often due to allergies or an abnormal reaction to certain medications, and the appearance of the eyes may help in the differential diagnosis. Systemic diseases that cause eye swelling are most commonly associated with heart and kidney disease, and systemic diseases such as systemic lupus erythematosus. In the case of cardiac diseases, the presence of heart failure symptoms, such as panic attacks after activity or waking up at night, can be identified by an electrocardiogram and ultrasound of the heart. In the case of kidney disease, the eyes appear puffy and the ankles are prone to swelling, and there can be an increase in the foam in the urine, which does not disappear within 10 minutes. In the case of systemic diseases of the rheumatic system, commonly systemic lupus erythematosus, skin rashes can appear, especially on the face, and can also induce puffiness in the eyes, which can also be accompanied by alopecia or painless mouth ulcers, and immunological markers in the blood can be abnormal, which can help in the differential diagnosis.