? Parkinson’s disease (PD) is a common movement disorder disease in neurology, mainly affecting middle-aged and elderly people. At present, patients with Parkinson’s disease in China have gradually reached half of the world, and the severity of treatment is in front of neurologists. It is understood that in the southern region of China, the First Hospital of Sun Yat-sen University has explored a good model of multidisciplinary cooperation for the integrated treatment of Parkinson’s disease after years of practice: medication is the basis, neurosurgical surgery is the enhancement, and rehabilitation therapy in the rehabilitation department is the supplement. So what are the advantages of this model? Drug therapy is the basis Parkinson’s treatment drugs have new formulations on the market According to Dr. Chen Ling, chief physician of the Department of Neurology of the First Hospital of Sun Yat-sen University, Parkinson’s disease is a common disease in neurology, according to incomplete statistics, in 2014, the Department of Neurology of the First Hospital of Sun Yat-sen University received 1000 visits to the Parkinson’s disease specialist, plus the professor’s outpatient clinic as well as general outpatient clinic should exceed 3000 visits. At present, the current status of Parkinson’s disease treatment is that patients who visit the clinic are characterized by long disease duration, complex conditions and unsatisfactory treatment results, and there is no lack of patients with unknown diagnosis. The vast majority of Parkinson’s patients are still treated with drugs, and there are six types of drugs for Parkinson’s in China, and new dosage forms of the drugs being used should be available this year. Dr. Chen Ling, chief physician, pointed out that in the use of drugs for Parkinson’s patients, the main combination of the correct choice of drugs, reasonable with the disease is the key, in addition, take into account the side effects of drugs and the patient’s financial ability. Deep brain stimulation (DBS) surgery requires long-term follow-up with neurology and surgery. Some patients have developed motor complications and the efficacy of medications has diminished after 4 to 5 years of disease. Surgery is minimally invasive and has proven efficacy, but many medical professionals and patients are not aware of this treatment, and the number of patients with Parkinson’s disease treated with surgery in China is far less than in Japan. Are there any complications with DBS surgery? Dr. Chao Yang, deputy chief of neurosurgery at the First Hospital of Sun Yat-sen University, introduces us to DBS therapy, which mainly involves implanting electrodes into the patient’s brain and using pulse generators to stimulate the nuclei in the deeper part of the brain to correct abnormal brain electrical circuits, thereby reducing the symptoms of neurological dysfunction. Unlike destructive surgery, DBS surgery is reversible and does not destroy brain structures. Moreover, DBS surgery is minimally invasive, and patients remain awake during the procedure without pain or irritation, and can answer questions from the neurologist while operating, as well as move their limbs as instructed; therefore, complications are rare. DBS therapy requires the cooperation of neurology and neurosurgery, and the First Hospital of Sun Yat-sen University is an example of this model. 2013, a multicenter clinical study led by the First Hospital of Sun Yat-sen University on DBS for Parkinson’s disease confirmed its safety and effectiveness, which is consistent with foreign reports. However, many patients are not aware of these data. In the past few years, many patients with Parkinson’s disease in Guangdong chose to go north for DBS, and often encountered a problem after surgery: patients need to be programmed and adjust their medication according to their condition after surgery, which requires long-term follow-up and the participation of experienced neurologists, and if they cannot be treated nearby, it is an added hassle for patients and they may not really This requires long-term follow-up and the involvement of experienced neurologists. Multi-disciplinary rehabilitation There are also internationally accredited techniques for speech rehabilitation in Parkinson’s disease Medications and surgery are not effective for some symptoms such as swallowing, speech and gait, making rehabilitation an important and effective supplement. In the latest version of Parkinson’s disease treatment guidelines, rehabilitation has become an integral part of the treatment. The Department of Rehabilitation at the First Hospital of Sun Yat-sen University has been the first in China to offer Parkinson’s rehabilitation therapy since 2006, including several major components of physical therapy, occupational therapy, speech and swallowing therapy. The Department of Physical Therapy provides physical therapy such as electrotherapy, magnetotherapy and pneumatic therapy to relieve patients’ ankylosis and pain, and provides guidance on balance, transfer, walking and coordination training. The speech therapy department focuses on swallowing and speech training to reduce swallowing and choking and to improve speech communication skills. Most of the patients receive exercise instruction and treatment in the outpatient clinic, with regular follow-up visits, while a small number of patients are hospitalized for a short period of time. The exercise prescriptions are customized by professional rehabilitation doctors and therapists according to the patients’ dysfunctional conditions to ensure that the patients master the appropriate training methods and eventually internalize them into their own home exercise regimen. Dr. Xi Chen, deputy chief physician, and several professional therapists focus on clinical research and work on Parkinson’s rehabilitation. Among them, speech therapist Yongxue Li is the only professional therapy technician in China who has obtained the certificate of LSVT therapy (currently the only internationally recognized speech therapy technique with long-term therapeutic effect on Parkinson’s patients); the speech pathology laboratory of the rehabilitation department is the leading professional speech analysis laboratory in China, and Hanjun Liu Professor Liu Hanjun is a talent introduced from Sun Yat-sen University, he used to be engaged in Parkinson’s disease speech therapy research at New York University in the United States, and is currently focusing on the research of Parkinson’s disease speech phonetic analysis and speech training related equipment development. It is understood that the team is developing a small similar “hearing aid” device, Parkinson’s patients can wear in the ears, playback the patient’s own voice, through the recognition of this instrument, the patient can properly adjust the volume of their own speech. In addition, the domestic language training specifically for Parkinson’s is relatively small, many treatment techniques are in accordance with the “stroke” to do, but Parkinson’s language disorders and stroke are significantly different: Parkinson’s disease affects speech and swallowing is mainly due to the patient’s muscle tone disorder, performance in the throat, language appears “dysarthria”, can express but cannot speak clearly, the voice is very low, the tone is very flat, the more you speak the smaller the voice; stroke patients mostly show language comprehension disorder or cannot find words to express themselves, medically known as aphasia. The speech training in Zhongshan First Hospital is to reduce the muscle tension of the throat and improve the coordination between muscle groups through some professional training methods and rehabilitation physiotherapy to help patients’ volume increase and promote speech rhythm improvement. Summary: The treatment of Parkinson’s disease is a long-term process that requires not only a scientific treatment plan and treatment techniques, but also requires patients to use medication in a standardized and reasonable manner for a long time under the guidance of a doctor, cooperate with follow-up visits, and insist on doing the right rehabilitation treatment. If all these components are closely coordinated and completed by a professional medical team, it is believed that not only can the patient’s motor function and non-motor symptoms be greatly improved, but also the time frame for self-care can be extended and the quality of life improved.