Blood creatinine 500μmol/L suggests entering the stage of renal failure, which is more serious, including acute renal failure and chronic renal failure. 1. Acute renal failure: refers to a series of clinical symptoms caused by a variety of causes of rapid decline in renal function. Once discovered, the cause should be corrected in time to control the development of the disease. If not treated in time, it can lead to irreversible damage of renal function. 2. Chronic renal failure: it is the common outcome of multiple chronic kidney diseases that continue to progress to the end stage, and the renal damage is irreversible. At this time, the main purpose of treatment is to delay the progression of renal function and prevent the deterioration of renal function, and those who meet the indication of dialysis should establish vascular access in advance. If there is an increase in creatinine, you should be alert and go to the hospital in time for treatment under the doctor’s guidance.