NSAIDs are preferred for osteoarthritis. NSAIDs are a class of antipyretic, analgesic and anti-inflammatory drugs that can reduce inflammation in the joints, relieve joint pain, reduce joint stiffness and improve joint function. Commonly used drugs are ibuprofen, indomethacin, naproxen, diclofenac sodium, etc. However, these drugs are prone to gastrointestinal side effects when taken for a long period of time, and are forbidden to be used if you have gastric ulcers or gastrointestinal bleeding. You can choose drugs that have little effect on the gastrointestinal tract, such as celecoxib and erliximab. Topical non-steroidal anti-inflammatory drugs can be applied topically, such as diclofenac diethylamide emulsion or ibuprofen cream. In addition to the above medications, chondroprotective agents can be applied, such as joint injections of sodium vitrate, which require hospitalization.