If the low pressure is high and cannot be lowered by taking medication, consider whether there are secondary factors, or whether there are problems with the medication, or whether the lifestyle habits have improved. 1. Secondary factors: If there is high low pressure, consider whether there are secondary factors, such as pheochromocytoma, cortisolism, or kidney function is damaged and worsened, which may cause the blood pressure is difficult to control, and then should be rooted out the primary disease. 2. Drug problem: If the low pressure peak drug still can not be reduced, consider whether taking drugs is appropriate, if taking drugs is not appropriate, there may be a decrease in renal function. If you choose angiotensin-converting enzyme inhibitors, the process of taking them may also cause the deterioration of renal function, resulting in difficult to reduce blood pressure. 3. Lifestyle habits: If you have a high blood pressure and can’t lower it with medication, consider whether your lifestyle habits haven’t improved, such as excessive salt load, which may also cause difficulty in lowering your blood pressure. In addition, if you are in a situation of long-term anxiety, fatigue, etc., the blood pressure will also be difficult to reduce the situation. If the low pressure is high and cannot be lowered by taking medication, it is recommended to closely observe one’s own situation, and if there is any abnormality, it is recommended to consult a doctor in time to find out the causative factors, and follow the doctor’s instructions to carry out symptomatic interventions.