White spots in the mouth of newborns can be caused by milk accumulation, palatal epithelial beads, thrush and other factors. 1. Milk accumulation: After a newborn baby eats milk, due to the inability to brush the teeth and other oral cleaning, milk accumulation in the mouth can form lumps of milk, which can appear small white spots like manifestations. It is necessary to pay attention to the use of soft sterile gauze dipped in warm water to clean the mouth after feeding. 2. Palatal epithelial beads: white rice-like bumps can be seen on the palate of the newborn’s mouth and at the edges of the teeth, mainly formed by the accumulation of epithelial tissue, which can be manifested as white spots. Usually no special treatment is needed and it will disappear naturally after a few months. 3. Thrush: after the emergence of thrush in newborns, milky-white clots can appear in the oral buccal mucosa, palate, gums and other parts of the mouth, mainly due to the infection of Candida albicans, and need to consult a doctor in time. Newborns with white spots in their mouths should seek medical attention in a timely manner, and after clarifying the condition, actively carry out the appropriate treatment, which will help to alleviate the discomfort as soon as possible.