Perianal wetness may be caused by allergy to the surrounding environment, food, etc. It can usually be treated with Benadryl, Loratadine and other drugs under the guidance of a doctor. 1. Benadryl: Benadryl is used for skin and mucous membrane allergy, perianal wetness is usually caused by the patient’s lack of attention to hygiene, food allergies and other local allergic reactions, skin and mucous membrane edema, etc., you can use Benadryl to carry out the treatment, after the use of the patient may appear shortness of breath, chest tightness, coughing, etc., to other ethanolamines highly allergic to the person who is prohibited to use this drug. 2. Loratadine: Loratadine is used to relieve allergy-related symptoms, such as itching, rash, redness and swelling of the skin, after the use of the patient may appear tiredness, headache, drowsiness, dry mouth and other symptoms, the drug is allergic to the components of the patients prohibited this drug. In addition to allergies, there may be many other causes of perianal moisture, it is recommended that patients should first go to the hospital for examination, to clarify the cause of the disease, and then under the guidance of the doctor reasonable use of drugs, pay attention to personal hygiene.