Most of the cases of pain in the male perineum are considered to be related to factors such as vesiculitis, epididymitis, varicocele, etc. The specific cause of the disease requires the patient to go to a regular hospital, a clear diagnosis under the guidance of the doctor, and targeted treatment. 1. Vesiculitis: patients may have ejaculatory pain, lower abdominal discomfort, urinary frequency, urinary urgency and other symptoms, should be promptly examined and diagnosed, through the sensitive antibiotic medication conditioning, serious cases need surgical treatment. 2. Epididymitis: patients may have swelling and pain in epididymis, need to choose sensitive antibiotics for treatment, commonly used drugs include cephalosporins, quinolones, macrolides. When drug treatment is not satisfactory, surgery is needed. 3. Varicose veins: patients may have enlarged scrotum on the affected side, accompanied by swelling and vague pain. Cooling treatment can be used, drug therapy such as hepatic saponins, flavonoids, serious cases need surgery. Patients with pain in the perineal area should go to the regular hospital in a timely manner for routine ultrasound examination of the genitourinary system, routine urinalysis, physical examination, etc., according to the results of the examination to analyze and clarify the specific causes for targeted treatment.