High blood antibodies to H. pylori indicate that there may be a current or previous H. pylori infection. Previous infections that have cleared usually do not require treatment, and the antibodies will return to normal in 6-12 months. Current infections are treated with quadruple therapy, a combination of a proton pump inhibitor, a bismuth agent, and two antibiotic drugs. For previous H. pylori infections, it may take 6-12 months for antibodies to return to normal because they are not cleared in a timely manner. A quadruple therapy including a proton pump inhibitor, bismuth, and two antibiotics may be used for patients with current infections. The commonly used drugs are listed below: 1. Proton pump inhibitors: e.g. Omeprazole, Rabeprazole, Pantoprazole, etc. They can effectively inhibit the secretion of gastric acid and alleviate the uncomfortable symptoms caused by excessive gastric acid secretion. 2. Bismuth: e.g. bismuth potassium citrate colloid, colloidal bismuth pectin, etc., which can play a role in protecting gastric mucosa, and at the same time have a certain inhibitory effect on Helicobacter pylori. 3. Antibiotics: for example, amoxicillin, levofloxacin, metronidazole, tinidazole, roxithromycin, etc., which have the effect of killing H. pylori, and need to be used in combination with the above two drugs. All of the above medications should be directed by a doctor, patients should not use the medication on their own, and please check regularly during the medication period.