Lung nodules that are benign usually do not affect HPV vaccination, but malignant nodules are recommended to be treated before considering whether or not to receive the vaccine. Lung nodules if benign nodules, the regular review, dynamic observation of nodules with or without change can, usually does not affect the vaccine; if malignant nodules, it is recommended that the vaccine is not, first for malignant nodules to take the appropriate surgery, radiotherapy and other treatments, to be stabilized and then consider whether to vaccinate. In addition, it should also be noted that if there are fever, cough, sputum and other signs of acute inflammation at the same time also do not recommend vaccination, so as not to affect the recovery of the disease or make the chances of adverse reactions after vaccination increased. It is recommended to consult a medical professional before vaccination to ensure the appropriateness of vaccination.