Mixed Connective Tissue Disease cannot be completely cured at present, but with active treatment, it can effectively improve the patient’s symptoms and quality of life. Mixed connective tissue disease is mainly caused by immune abnormalities, family genetics and other factors, and can involve most of the major organs and systems of the body. Prednisone and other glucocorticoids can be used to treat arthritis, pleurisy, myositis and pericarditis caused by mixed connective tissue disease. Immunosuppressants such as methotrexate and cyclophosphamide can also be used to alleviate the progression of the disease, but they cannot eradicate the cause of the disease or completely cure mixed connective tissue disease. It is recommended that patients go to the rheumatology and immunology departments of regular hospitals for consultation and standardized diagnosis and treatment in accordance with the doctor’s instructions.