Newborns with three-day jaundice of 15 to 18mg/dL are pathologically jaundiced, and should be alerted to the persistent elevation of jaundice index, and it is recommended to consult the doctor as soon as possible for treatment. Due to immature liver development, bilirubin is not easy to be discharged, and jaundice is easy to be produced in newborns. The normal value should be no more than 15mg/dL, and if it exceeds that, the jaundice index is on the high side, which is pathologic jaundice. The jaundice index of a newborn reaches its peak in three to five days after birth, and if the jaundice index exceeds 15mg/dL at this time, we should be alerted, and recommend consulting the neonatology department as soon as possible. Hyperbilirubinemia should be alerted when the neonatal jaundice index continues to rise at a rapid rate. Increasing jaundice and hyperbilirubinemia can cause brain damage and adversely affect neonatal brain development. Hyperbilirubinemia, if treated promptly, can minimize sequelae and other adverse effects. Once an abnormally high jaundice index is detected, prompt medical treatment should be sought to avoid delay in treatment.