Connective tissue disease may develop into pleurisy, heart damage, impaired kidney function and other diseases in the later stages, involving multiple organ systems throughout the body, which may be life-threatening in severe cases. Connective tissue disease is an autoimmune disease with multi-organ and multi-system involvement, and the cause of the disease is related to abnormal immune function, genetics and other factors. If connective tissue disease is not treated in time, it may develop into pleurisy, interstitial lung lesions, heart damage, impaired renal function, meningitis and other diseases in the later stages, and there may also be enlargement of the liver, spleen and lymph. Connective tissue disease may involve multiple systems and organs, the condition is more complex, if not treated in time, may cause multiple organ function damage, and in serious cases, may also be life-threatening. It is recommended that patients with connective tissue disease go to the hospital in time and follow the doctor’s instructions for symptomatic treatment.