I. Preface: Peptic ulcer, including gastric ulcer and duodenal ulcer, is a very common and stubborn disease. Statistically, 1/4 of men and 1/6 of women will develop the disease during their lifetime. Only a small percentage (5-10%) of these cases have symptoms. Because today’s society in general, life is stressful, the diet is not normal, addicted to alcohol and tobacco, so the prevalence of peptic ulcer a sting high, not only endanger the health of the country to huge and consume a lot of social resources, it is necessary to let everyone know more about the disease. Second, the pathogenic mechanism: research shows that peptic ulcer is multifaceted; including congenital factors (genetic inheritance) and acquired factors (Helicobacter pylori, smoking, drinking, painkillers and anti-inflammatory drugs) lead to an imbalance between gastric acid and gastrin, as well as the destruction of the gastric mucosa resistance mechanism, and finally produce peptic ulcer. Among them, duodenal ulcers are highly correlated with hyperacidity, H. pylori, and smoking. Gastric ulcer patients with normal or low gastric acid secretion, and with bile, pancreatic reflux, pain-relieving and anti-inflammatory drugs, alcohol, etc., the destruction of gastric mucosal resistance mechanism turn has a great relationship. Third, clinical symptoms: the most common symptom is epigastric pain, duodenal ulcer usually on the abdominal pain when hungry on an empty stomach, eating will relieve the pain. Gastric ulcers may have upper abdominal discomfort after eating. In addition to epigastric pain, dyspepsia including hiccups, vomiting, loss of appetite, epigastric distention, and epigastric discomfort are also common. Fourth, complications: 1, bleeding: is the most common cause of upper gastrointestinal bleeding. Peptic ulcer patients have 10-15% complications of bleeding. Elderly patients (over 60 years old) with chronic diseases including liver cirrhosis, diabetes, hypertension and ischemic heart disease, uremia, cancer, etc., are all at high risk of bleeding and need special attention for treatment. 2, perforation: about 5-10% of duodenal ulcer patients and 2-5% of gastric ulcer patients will continue to erode the stomach wall or duodenal wall because of ulcers, finally leading to perforation, resulting in peritonitis, this is the most serious and critical complications of peptic ulcer, must be diagnosed early, immediately surgical treatment, otherwise the mortality rate is very high. 3. Obstruction: Chronic gastric ulcers near the pylorus or lower gastric antrum may block the gastric outlet because of inflammation, spasm and fibrosis. Similarly, duodenal ulcers can produce pyloric obstruction due to the same condition. Diagnosis: When a patient complains of epigastric pain for more than a week, the doctor should consider gastroscopy or upper gastrointestinal tract photography to rule out the possibility of peptic ulcer. Among them, gastroscopy is the most direct and accurate diagnostic tool; when needed, gastroscopy can also implement treatment and disposal such as hemostasis, early gastric tumor resection, pathological section, etc. Treatment: At present, there are already very effective methods to cure the disease. Generally speaking, after one to two months of antigastric acid treatment, plus one to two weeks of H. pylori eradication therapy, about 90% of patients will not recur for life. Seven, conclusion: to get rid of the danger of peptic ulcer, take the medicine on time and in full, quit smoking, quit drinking, and change the bad life and diet habits, is the best way to avoid recurrence.